Measurement of the swelling force in ionic polymeric networks: II. Swelling force and disintegration of controlled release dosage formulations using pH-sensitive components
نویسندگان
چکیده
The swelling behavior of disintegrating agents produced from microparticles of crosslinked, hydrophilic polymers was investigated as a function of time by using a swelling force measurement apparatus. The swelling force produced due to swelling of poly(acrylic acid-co-2-hydroxyethyl methacrylate) and poly(acrylic acid) was measured in various buffered solutions as a function of time and the swelling ratio of the continuously swelling polymer. The results were related to the swelling mechanism of disintegration.
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